The Scots were knocked out of the World Cup play-offs by Wednesday’s visitors.
But Clarke thinks it will not have the “same edge” as when Ukraine arrived so soon after Russia’s invasion and won 3-1 at an emotional Hampden Park.
“That one in June was pretty unique – the circumstances leading into it,” Scotland’s head coach said.
“It will be slightly different but still a big game. Yes, they will be fired up, they are a good team, they want to top the section and get promotion to the A group of the Nations League, but so do we.”
Scotland sit second in Group B1, a point behind Ukraine, after a 3-0 loss away to the Republic of Ireland sandwiched between home and away wins over Armenia at the tail end of last season.
“I am sure Ukraine will play to the same level, but what I’m looking for from our team is that we get back to the level that we can be and then we’ll see what the result is,” Clarke said.
“I just feel that, in the summer, we stalled a little bit and we want to start that forward momentum again.”
Oleksandr Petrakov’s visitors went on to lose their World Cup play-off final in Wales but arrive unbeaten in the Nations League having beaten the Republic in Dublin and Armenia at home before the Irish held them to a draw in their temporary home of Poland.
Clarke says he has been working on ways to combat “a very good team, very comfortable on the ball, good in possession and who showed they can play on the counter attack as well”.
Commentator’s notes – analysis
BBC Scotland’s Liam McLeod
These are crucial times for both teams as they chase top spot in this Nations League section.
The good news is that Arsenal’s Oleksandr Zinchenko, outstanding in the World Cup play-off encounter in Glasgow, misses out through injury. He was tormentor in chief on a night Ukraine were streets ahead of their beleaguered and well below-par hosts in every department.
However, the other nine outfield players from the starting 11 are back in Glasgow for this one.
Technically, the Ukrainians were as good as any national team that has played the Scots at Hampden Park in the last decade or so, even if Clarke’s men were well off the pace.
Young Dynamo Kyiv centre-back Iliia Zabarnyi, Everton wing-back Vitaliy Mykolenko, Atalanta midfield powerhouse Ruslan Malinovskyi and veteran skipper Roman Yarmolenko, who scored the first against the Scots in that play-off, are all likely starters again.
The other scorers at Hampden were strikers Roman Yaremchuk and substitute Artem Dovbyk who are fighting to lead the line.
Clarke will be able to take some solace from the fact that Wales went onto beat the Ukrainians in the play-off final while Ireland managed a point in Poland against them, so a positive outcome is achievable.
The latter of those results is one that has reignited Scottish hopes for a triple-header that should not be underestimated with the Euro 2024 qualifying draw just over a fortnight away.
Promotion to Nations League A is almost of secondary importance to the slot in the European Championship play-offs that is guaranteed for the group winner alongside a place in pot two for the draw in Frankfurt.
Ukraine are currently in pole-position for those prizes.
Clarke’s options in defence have been severely reduced after Norwich City’s Grant Hanley dropped out of a squad already shorn of fellow centre-backs John Souttar and Liam Cooper, as well as captain Andy Robertson.
Celtic’s Greg Taylor and Brentford’s Aaron Hickey will compete for the left wing-back role in the Liverpool man’s absence.
Back-up goalkeeper Jon McLaughlin also dropped out with injury, to be replaced with Rangers team-mate Robby McCrorie, along with Stoke City forward Jacob Brown.
Ukraine will be without the influential Oleksandr Zinchenko, the Arsenal left-back/midfielder having picked up a calf injury in training.
Club Brugge left-back Eduard Sobol and Dynamo Kyiv midfielder Mykola Shaparenko also miss out through injury.
What they said
Scotland midfielder Stuart Armstrong: “We acknowledged the previous game wasn’t good enough and where things went wrong – to have a second go always helps. There is definitely a level of hurt there from the last time and we obviously knew what was at stake and the disappointment following that.
“We know they are difficult opponent – we know that from last time – but equally we know our own capabilities and the results we’ve had in the past can show we are also a very good team.”